The causes of lupus are unknown. It is thought that a combination of factors may work together to trigger the development of the condition, including:
Genetic (inherited) factors
Although uncommon, the tendency to develop the condition may run in families giving rise to the theory that genetic factors influence its development.
Some research has indicated that lupus is triggered by the abnormal response by the body’s immune system to a viral infection.
Because substantially more women than men suffer from lupus, and because some women experience worsening symptoms at the time of their menstural periods, female hormones are thought to play a role in the development of the disease.
It is known that some medications, such as those used for treating epilepsy, rheumatoid arthritis, high blood pressure and heart conditions, can lead to the development of lupus symptoms. When this occurs it is referred to as drug-induced lupus. This is a rare occurrence, however, and symptoms disappear when the medications are stopped.
Signs and symptoms
The first symptoms of lupus may be vague. There may be a feeling of being generally unwell or of having a continuous dose of the flu. Muscle and joint aches, and fever may also be present. Subsequent symptoms may include:
- Loss of appetite
- Weight loss
- Skin rashes - most commonly a characteristic rash across the nose and cheeks known as the "butterfly rach" or "malar rash"
- Hair loss
- Mouth and nose ulcers
- Red sore dry eyes
Heart and lungs
Inflammation of the outer lining of the lungs (pleurisy) may cause chest pain and shortness of breath. Inflammation of the outer or inner lining of the heart (pericarditis, endocarditis) may also cause chest pain and lead to other problems such as heart rhythm disturbances, damage to the heart muscle and heart failure. The arteries that supply blood to the heart may also become inflamed (coronary vasculitis), affecting the amount of blood able to reach the heart muscle. Again this may produce symptoms such as chest pain (angina) or shortness of breath.
Inflammation can damage the delicate filtering structures within the kidneys. This can reduce their ability to filter the blood and can lead to alteration in kidney function, and in some cases, kidney failure.
Some people with lupus may experience nausea, vomiting, diarrhoea or abdominal pain due to inflammation of the structures and organs within the abdomen.
Lupus can affect the brain or central nervous system in some people causing headaches, seizures, vision problems and dizziness. Personality changes and depression can also occur.
Blood and blood vessels
People with lupus may develop anaemia (lack of oxygen carrying haemoglobin in the blood) or leucopaenia (a decreased number of infection fighting white blood cells). These conditions often compound the feeling of fatigue and ill health. Inflammation of the blood vessels (vasculitis) may also occur and some people with lupus may have an increased risk of blood clots.
Arthritic pain, stiffness and swelling of the joints can occur - especially in the small joints of the hands and feet. Muscle aches are common and distortion of the hands due to inflammation in the tendons occurs in approximately 20% of cases. There may also be an increased tendency to develop osteoporosis (loss of bone mass).
Other conditions can occur at the same time as lupus, including fibromyalgia, coronary heart disease, pancreatitis and infections.
Complete blood count
This will show the number of red and white blood cells. Lower than normal white and red blood cell counts are associated with lupus
This will show the balance of electrolytes in the body and can indicate abnormalities with the function of the kidneys and other internal organs.
Erythrocyte sedimentation rate (ESR)
This is a measure of red blood cells (erythrocytes) settling in a test tube over a given period of time.An elevated ESR indicates the presence of inflammation in the body.
Antinuclear antibody test (ANA)
The ANA test detects the presence of autoantibodies. This test is positive in 95% of lupus cases, however there are a number of other causes for a positive ANA result, including other autoimmune diseases and infection. If the test is negative, lupus is unlikely.
Other autoantibody tests
Sometimes tests for other autoantibodies that are specific to lupus are performed to confirm a diagnosis. These may include tests for complement enzymes, antiphosphiloid antibodies, lupus anticoagulant and antibodies to DNA (anti-dsDNA).
These measure the clotting ability of the blood. Abnormalities can be associated with an increased risk of blood clots in some people with lupus.
If lupus is suspected or confirmed a referral to a specialist (usually a rheumatologist) may be recommended.
Anti-inflammatory medications such as aspirin, and non-steroidal anti-inflammatory drugs (NSAID's) such as Brufen and Voltaren, can help to reduce pain and inflammation. To avoid irritating the stomach, it is recommended that these medications be taken with food or with a stomach protectant such as misoprostol (Cytotec). Other medications that may be used include:
Anti-malarial medications - It is not entirely clear how these medications work to treat lupus, however it is thought that they reduce the autoimmune response. An anti-malarial medication commonly used in the treatment of lupus is Hydroxychloroquine.
Immunosupressive medications - These help to dampen down the abnormal response of the immune system and can be given as tablets or as an infusion into a vein. Immunosuppressive medications are used for treating people with more severe disease, such as when there is damage to internal organs. Examples of these medications include azathiaprine (Imuprine), methotrexate (Methoblastin), cyclophosphamide (Cycloblastin) and mycophenolate mofeti (Cellcept) which is particularly useful for people with kidney disease.
Biological medications - These are synthetic (man-made) antibodies that suppress specific components of immune system function. They include rituximab (Mabthera) which is also helpful for people with kidney disease, and belimumab (Benyista).
Rest and Exercise
Rest will help reduce fatigue, pain and inflammation. Exercise is also important to maintain muscle strength, decrease joint deformities and stiffness, and to maintain mobility. A physiotherapist can recommend an appropriate exercise regime. When lupus is more problematic, more rest is required.
Because sunlight can trigger flares and skin rashes in some people with lupus, it is important that lupus sufferers who are sensitive to the sun should avoid sun exposure, particularly between 11.00am and 3.00pm. Protective clothing and sunscreens with a sun protection factor of 15+ should be worn when in the sun.
Reducing stress is vital for people with lupus and many people find that techniques such as meditation, yoga and hypnotherapy can assist with stress reduction. Acupuncture and massage is effective for some people in reducing joint and muscle pain.
Dietary factors are also important and a diet low in red meat and dairy products is thought to help reduce pain and inflammation. Also, some foods, such as alfalfa sprouts, and dietary supplements, such as Echinacea, have been implicated in causing lupus flares and should be avoided. Homeopathy and vitamin supplements may also assist with overall improved health.
It is important to discuss any alternative therapies with the doctor or specialist before undertaking them to insure that they will not interfere with medical treatments. For advice on dietary factors, consult a dietician.
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