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Southern Cross Medical Library

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Menopausal hormone therapy (MHT)

 

Menopausal hormone therapy (also known as hormone replacement therapy or HRT) is the terminology used for prescription medications containing female hormones.  The purpose of MHT is to relieve symptoms relating to estrogen (female hormone) deficiency.   

MHT is prescribed as estrogen alone therapy (in women who have undergone hysterectomy), estrogen and progesterone therapy (in women who have a uterus) and in special circumstances, testosterone may also be included. 

The most common indication for MHT is to relieve unpleasant menopausal symptoms which may affect a woman’s quality of life, particularly sweats and flushes, sleep disturbance and cognitive symptoms such as anxiety and depression associated with menopause.  Other indications for MHT include treating or preventing osteoporosis and alleviation of the genitourinary syndrome of menopause (vaginal dryness, discomfort, urinary frequency and urgency). 

Southern Cross gratefully acknowledges this article's authors: Drs Megan Ogilvie and Stella Milsom of Fertility Associates, Auckland.

General information

During menopause, levels of oestrogen and progesterone production gradually decrease.  As a woman’s body adjusts to these changing hormone levels, menopausal symptoms – commonly hot flushes, increasingly erratic periods, night sweats and vaginal dryness can occur.  Other symptoms may include joint aching, mood change, anxiety and fatigue.   During and after the menopausal transition women also lose bone density and the risk of osteoporosis increases.

The duration and intensity of menopausal symptoms varies considerably between women.  The average duration of symptoms is seven and a half years after the last menstrual period.  Some women are symptomatic even before periods become irregular.   For a small percentage of women (about 20%) symptoms persist into later life.  Some women pass through the menopause without noticing any symptoms; other women report severe symptoms.

How MHT is prescribed

The hormone that alleviates symptoms is estrogen.   New Zealand has natural, “body-identical” estrogen (oestradiol) available which can be prescribed in tablet, patch or vaginal pessary or cream formulation.  Progesterone is needed in all women with a uterus (unless only vaginal estrogen is prescribed) to balance the estrogen and is usually prescribed as a tablet or as an intrauterine device (Mirena and Jaydess IUD).   

Some formulations are fully funded and some involve a part charge.  Not all delivery methods are appropriate for all women.  Some regimens mimic the menstrual cycle, so that monthly bleeding occurs.  Continuous combined oestrogen and progesterone leads to an absence of periods in most women.   Your doctor will be able to discuss the pros and cons of various formulations.

Oestrogen gel, oestrogen implants and a combined oestrogen and progesterone patch have limited availability in New Zealand and are not funded.  

MHT benefits and risks/side effects

Benefits of MHT include:

  • Relief from menopausal symptoms - oestrogen is the most effective treatment for menopausal symptoms.
  • Treatment of the genitourinary syndrome of menopause (GSM, previously referred to as vaginal atrophy) 
  • Protection and treatment for lowered bone density (osteoporosis)

Risks of adverse events are very small in healthy women, and vary depending on whether oestrogen is given alone or in combination with progesterone:  

  • 4-7/additional venous clots per 10,000 women treated per year (estrogen delivered by a patch or gel has not been associated with any venous clot risk)
  • Oestrogen and progesterone MHT may possibly increase breast cancer risk in some women by 1 additional event per 1200 women per year after 5 years of treatment after the age of 50 years.  Risk returns to baseline a few years after stopping MHT
  • Oestrogen only MHT does not increase breast cancer risk
  • For women over the age of 60 years there may be a small increased risk of a heart attack or a stroke.  This small risk is likely even less if estrogen is delivered via low dose patch (< 50 ug per day) 

Side effects:

  • There can be breast tenderness and some dysfunctional bleeding.  Dose adjustments can usually minimise or alleviate these side effects.

How to use MHT

Oestrogen treats the menopausal symptoms and protects bone density.    The progesterone component controls menstrual bleeding and protects from cancer of the endometrium (lining of the womb).  Women who have had a hysterectomy are most often prescribed oestrogen alone.  Women who have a uterus need progesterone as well as the oestrogen.   MHT is not contraceptive.

Before prescribing MHT the doctor will take a full medical history.  The following are relative contraindications for MHT and a woman should advise her doctor if there is any history of the following:

If any of these conditions are present, consideration should be given to prescribing non hormone alternatives such as clonidine, or the serotonin medications or gabapentin.

Continuing on MHT 

Once the appropriate dose and route of MHT has been established (sufficient to provided symptom relief without side effects), it is recommended that a woman has an annual check up with her doctor.   At each follow up, the doctor will monitor weight, blood pressure and perform a breast examination.   

There is no set recommended duration of treatment; each year a woman and her doctor will assess benefits of treatment versus any small risks based on the woman’s individual health and medical history.  It is suggested that women consider a wean off MHT from time to time to see if MHT continues to be required. 

Many women will only require treatment for a few years and most will come off MHT by their late 50s or early 60s.  However, age alone will not dictate the discontinuation of treatment.  If longer term therapy is considered necessary for adequate symptom relief, ie into the 7th decade of life, then it is recommended that consideration is given to forms of MHT associated with the least risks.   

When women discontinue systemic MHT, discussion around the continuation or initiation of vaginal oestrogen is suggested as symptoms of GSM are persistent in later menopause in at least 50% of women. 

References

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline.   American Endocrine Society, 2017 https://academic.oup.com/jcem/article/100/11/3975/2836060
The North American Menopause Society Guideline, 2017: http://www.menopause.org/docs/default-source/2017/nams-2017-hormone-therapy-position-statement.pdf
The Australasian College of Obstetrics and Gynaecology guideline, 2015 https://www.ranzcog.edu.au/RANZCOG_SITE/media/RANZCOG-MEDIA/Women%27s%20Health/Statement%20and%20guidelines/Clinical%20-%20Gynaecology/Menopausal-Hormone-Therapy-Advice-(C-Gyn-16)-Re-write-July-2015.pdf?ext=.pdf

  

Last Reviewed – November 2018

 

Southern Cross gratefully acknowledges this article's authors: Drs Megan Ogilvie and Stella Milsom of Fertility Associates, Auckland.

 

Southern Cross gratefully acknowledges this article's authors: Drs Megan Ogilvie and Stella Milsom of Fertility Associates, Auckland.

 

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