Ulcerative colitis - causes, symptoms, treatment
Ulcerative colitis is a form of inflammatory bowel disease that causes swelling, ulceration and loss of function of the colon (large intestine) and rectum. Bloody diarrhoea and lower abdominal pain are the most common symptoms.
Diagnosis of the disease normally requires endoscopic examination and biopsy tests. Ulcerative colitis is a chronic (long-term) condition that's likely to require ongoing treatment to address "flare-ups" and maintain periods of remission.
Ulcerative colitis can begin at any age but most commonly occurs in young adults between the ages of 15 and 25 years. The condition also has an increased incidence between the ages of 50 and 70 years. Children are rarely affected. Women are more commonly affected by the condition than men. Based on international estimates of the disease's prevalence, it's likely between 4,000 and 8,000 New Zealanders have ulcerative colitis.
The exact cause of ulcerative colitis is unknown. It has been hypothesised that it is an autoimmune disease in which the intestinal immune system attacks healthy intestinal cells and tissues. Susceptibility to this abnormal behaviour of the intestinal immune system may be genetically inherited. People who have a first-degree relative (i.e. brother, sister, child, parent) with ulcerative colitis are more likely to develop the disease. In recent years approximately 30 genes that might increase susceptibility to the disease have been identified. Environmental factors may also play a role.
Factors such as stress and eating certain foods do not cause ulcerative colitis but may worsen the symptoms.
Signs and symptoms
The most common symptoms of ulcerative colitis are episodes of bloody diarrhoea and pain in the lower abdomen. There may also be a sensation of urgent need to pass a bowel motion. The bowel motions may be explosive and may contain mucous or pus.
Other symptoms that may be experienced include:
- A general feeling of ill health
- Weight loss
- Loss of appetite
- Bloating of the abdomen
Symptoms vary in frequency and severity. Approximately half of all sufferers will experience only mild symptoms. However for others, symptoms will be more severe. The severity of the symptoms tends to be related to how much of the colon is affected.
Ulcerative colitis is characterised by episodes where symptoms are problematic (“flare-ups”) and episodes where symptoms are absent (remissions).
Ulcerative colitis patients may experience signs or symptoms outside the colon, such as ulcers in the mouth, inflammation of the iris (eye), arthritis, skin lesions, blood clots and anaemia.
There is an increased risk of colorectal cancer in patients who have had extensive ulcerative colitis for a number of years.
Ulcerative colitis may be suspected when a person has experienced symptoms of rectal bleeding, intermittent diarrhoea and abdominal pain.
As part of the diagnosis the doctor will take a full medical history and conduct a physical examination. The doctor may request that blood tests and specimens of the bowel motion are taken.
In ulcerative colitis, blood test results will often indicate anaemia and signs of inflammation in the body. Samples of bowel motions will often indicate the presence of blood, pus and mucous.
If ulcerative colitis is suspected, endoscopy may be recommended. Endoscopy is the most important diagnostic test used to diagnose ulcerative colitis. During this test a small flexible tube (an endoscope) with a fibre-optic camera at its tip is passed into the rectum and colon. The doctor is able to see the lining of the rectum and colon on a television screen and can look for signs of inflammation and ulceration that may indicate ulcerative colitis. Small tissue samples (biopsies) from the lining of the colon and rectum can be taken for testing. Ulcerative colitis can be diagnosed by the characteristic abnormalities of this tissue.
Ulcerative colitis most commonly affects the rectum and the lower part of the colon (the sigmoid colon) but can sometimes involve all of the colon.
X-ray tests using barium (a chalky liquid that is able to be seen on x-rays) can be helpful in determining how much of the colon is affected by ulcerative colitis. The barium is administered into the rectum and colon via a tube inserted through the anus. A series of x-rays is taken, showing the outline of the inside of the colon and highlighting any abnormalities.
Ulcerative colitis is related to another type of inflammatory bowel disease - Crohn's disease
. Some of the symptoms are similar but, whereas it is the large intestine and rectum that are affected by ulcerative colitis, Crohn's disease can develop in any part of the digestive tract.
Treatment for ulcerative colitis aims to prevent complications of the condition by reducing inflammation and maintaining periods of remission.
The type of treatment recommended will depend on the extent and severity of the condition. A person’s age, general health, lifestyle and personal choice will also be taken into account.
In very mild cases, modification of the diet and stress reduction may be all that are required to effectively manage symptoms. However in severe cases, surgery to remove the colon and rectum may be required.
Treatment options include:
While stress does not cause ulcerative colitis, it can worsen symptoms in some people. Developing techniques to reduce stress can be helpful in managing the condition.
There is no evidence to support any specific diet as a treatment for ulcereative colitis. Some foods, however, can worsen symptoms in some people. Keeping a food diary can be helpful in identifying which foods are problematic. Once identified, these foods should be avoided during flare-ups.
It may be recommended that vitamin and mineral supplements, such as iron and calcium, are added to the diet.
Some people have found that therapies such as massage, yoga, acupuncture and naturopathy have helped to manage their condition. It is advisable to discuss these with the doctor before starting them.
Treatment for ulcerative colitis usually involves the use of anti-inflammatory medications containing a medication known as 5-aminosalicylic acid (5-ASA). Examples of these medications include sulphasalazine (Salazopyrin), mesalazine (Pentasa, Asacol) and olsalazine (Dipentum). These reduce inflammation in the colon and rectum leading to a reduction in symptoms. These medications are usually taken on a long-term basis and can help prevent flare-ups.
Medications to suppress the immune system may be recommended. Examples of these include azathioprine (Imuran) and cyclosporin (Neoral). Infliximab (Remicade) - a new type of medication that modifies immune system function - is available for people with active ulcerative colitis whose symptoms are not adequately controlled with 5-ASA and corticosteroid medications. However, use of infliximab may be restricted by its high cost.
Severe flare-ups of ulcerative colitis may require hospitalisation. Corticosteroid medications, such as budesonide (Entocort CIR) and prednisone (Apo-Prednisone) may be required and can be given either by mouth (orally), through a drip (intravenously) or into the rectum (as an enema or suppository). Antibiotics may be required if infection is present in the colon.
Dehydration caused by profuse diarrhoea may need to be treated by giving fluids through a drip. Medications to relieve pain and diarrhoea may also be given.
Loss of blood through the rectum over a long period of time can lead to anaemia. Iron tablets may be prescribed to correct the anaemia and prevent its recurrence. In cases of severe blood loss, blood transfusions may be required.
In severe cases, where medication and supportive treatment have not been successful in controlling the condition, or where the side effects of medications are intolerable, surgery may be required. Approximately 20% of all people with extensive ulcerative colitis will require surgery at some stage.
There are three main surgical techniques for the treatment of ulcerative colitis.
Total proctocolectomy and ileostomy
This involves removing the entire colon and rectum. The end of the small intestine is brought out onto the wall of the abdomen. A collection bag is placed over the opening and faecal matter will pass into it. The bag is emptied by the person as required. The ileostomy is permanent. This type of surgery offers a permanent cure for ulcerative colitis.
Sub-total colectomy and ileorectal anastamosis
This is where most of the colon is removed, but the rectum is retained. The lower end of the small intestine is joined to the upper end of the rectum.
Ileoanal anastomosis (“Pouch operation”)
The entire colon and rectum are removed. A section of the small intestine is used to make a small pouch where faecal matter can be stored. The pouch is then attached to the anus. This surgical technique does not require a permanent ileostomy.
Support and Information
For further support and information contact the following:
Crohn's & Colitis New Zealand
Phone: 04 972 3149
Carson De-Witt, R. (2006) Ulcerative Colitis. The Gale Encyclopaedia of Medicine. Third Edition. Jacqueline L. Longe, Editor. Farmington Hills, MI. Thompson Gale.
Crohn's & Colitis New Zealand (2011). Ulcerative Colitis (PDF). http://crohnsandcolitis.org.nz/uploads/files/chapter_3.pdf
Crohn's & Colitis New Zealand (2011). Surgery in IBD (PDF). http://crohnsandcolitis.org.nz/uploads/files/chapter_5.pdf
Schoenfield, A., Wu, J.W. (2013). Ulcerative Colitis. MedicineNet.com. New York: WebMD LLC. O'Toole, J.M. (Ed) 2013) Mosby's Dictionary of Medicine, Nursing & Health Professionals (9th ed) St. Louis:elsevier Mosby.
Last Reviewed – May 2013
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